Primary induction of vitellogenin mRNA in the rooster by 17beta-estradiol.
نویسندگان
چکیده
منابع مشابه
Primary activation of the vitellogenin gene in the rooster.
Vitellogenin, the precursor of egg yolk phosphoproteins, is synthesized in the liver of the laying hen but is not normally synthesized by roosters. Administration of 17/?estradiol to roosters induces the synthesis of large amounts of this protein and its messenger RNA. We have purified vitellogenin messenger RNA from the livers of estrogentreated roosters and have characterized it as follows: (...
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17Beta-estradiol decreases hypoxic induction of erythropoietin gene expression.
Exposure to chronic hypoxia induces erythropoietin (EPO) production to facilitate oxygen delivery to hypoxic tissues. Previous studies from our laboratory found that ovariectomy (OVX) exacerbates the polycythemic response to hypoxia and treatment with 17beta-estradiol (E2-beta) inhibits this effect. We hypothesized that E2-beta decreases EPO gene expression during hypoxia. Because E2-beta can i...
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A primary monolayer culture system from cockerel hepatocytes was established. The cultures synthesize and secrete proteins that comigrate with authentic serum proteins on polyacrylamide gels and are found in the same relative abundance. Addition of estradiol increased the synthesis of apoprotein B, found in very low density lipoprotein, under all culture conditions. Vitellogenin synthesis could...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 1978
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.75.4.1815